RF-034Life Sciences & Health

ZETABODY

A modular biomedical research-software architecture for representing physiological signals, flow, tissue structure, genomic topology, molecular structure, and formally auditable reasoning.

ClassRF-A/RF-D/RF-E

Evidence TierTier 5 (Biomorphic Robotics)

Model ProfileCYBERPHYSICAL

AttributionAnna Paseva · GILC ZETABODY programme

Admitted MonolithZETABODY — Research Architecture Visual Plate

EPISTEMIC DEMARCATION // Tier 5 (Biomorphic Robotics)

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Constitutional Demarcation: A Research Fabric is a bounded epistemological architecture. Structural formulation, digital execution, and proof-assistant replay declare local invariants; they do not constitute unverified physical validation.

Research Question

How can heterogeneous biomedical information be organized into modular computational models that remain interpretable, auditable, provenance-aware, and suitable for later scientific evaluation?

Evidence Boundary

ZETABODY and all current modules have conceptual/software evidence only.

This means:

• no module is presented as clinically validated;
• no module is presented as a medical device;
• no module is presented as demonstrating diagnosis, prognosis, treatment efficacy, or prevention;
• proposed biomarkers, scores, alerts, classifications, or intervention pathways are software/research constructs until independently evaluated;
• formal verification can verify software/logical properties of a specification, but does not establish biomedical truth.

Architecture

ZETABODY is organized as a modular system rather than a single universal health model.

Signal and physiological-state modules

• ZetaCardio — cardio-autonomic and related physiological signal/rhythm modeling.
• Navisoma — vascular, lymphatic, cerebrospinal-fluid and related flow-oriented modeling.

Structural and biological-pattern modules

• Knotome — genomic/chromatin topology and structural-state modeling.
• Fibralytica — tissue morphology, deformation and multiscale image/pattern analysis.
• StructaFold — protein conformation and molecular/microenvironment structural modeling.
• QuantumKirchhoff — network/field-style computational modeling of coupled biological or microenvironment states.

Verification and governance modules

• ProofClinic — formally auditable clinical-reasoning software logic and verification layer.
• Motifin — genomic identity, compatibility, consent and rule-based targeting/governance layer.

The modules may exchange computational representations, but outputs retain the evidence status of the underlying source data and model.

Core Invariants

1. Software model ≠ clinical diagnosis.
2. Formal proof of code/specification ≠ proof of biomedical validity.
3. Each module must expose source data, assumptions and uncertainty.
4. Cross-module inference must preserve provenance.
5. No module may silently promote conceptual or simulated outputs into clinical evidence.
6. Consent and access constraints must remain attached to relevant data and outputs.
7. Human clinical judgment and regulated workflows remain outside the authority of the software unless separately validated and authorized.

Current Module Registry

Module	Primary software/research role	Evidence
ZetaCardio	Physiological signal/rhythm modeling	Conceptual/software
Navisoma	Vascular/lymph/CSF flow modeling	Conceptual/software
Knotome	Genome/chromatin topology modeling	Conceptual/software
Fibralytica	Tissue morphology/fractal-wavelet/topological analysis	Conceptual/software
StructaFold	Protein/conformation and molecular-structure modeling	Conceptual/software
QuantumKirchhoff	Coupled biological-network / microenvironment modeling	Conceptual/software
ProofClinic	Formal reasoning, verification and audit logic	Conceptual/software
Motifin	Genomic integrity/compatibility/consent logic	Conceptual/software

Evidence & Status

Current evidence is limited to:

• architecture and module definitions;
• computational concepts;
• software/formal-verification design;
• prototype-oriented research specifications where available.

There is no established clinical evidence layer in the current ZETABODY registry.

Research / Implementation Path

• specify module input/output contracts;
• define reference datasets and baseline methods;
• implement reproducible software pipelines;
• benchmark against established computational methods;
• perform retrospective research evaluation where lawful and appropriate;
• define prospective validation protocols only after software performance is characterized;
• keep clinical and regulatory claims gated until independently supported.

Publications & Primary Materials

No directly matched Zenodo publication for ZETABODY appears in the current publication registry.

Supporting media

• ZETABODY: Real-Time Intelligence for Human Health — project media; its predictive-health language is a programme objective, not validated clinical evidence.

Modules

Nested module records are maintained in the ZETABODY modules directory:

• ZetaCardio
• Navisoma
• Knotome
• Fibralytica
• StructaFold
• QuantumKirchhoff
• ProofClinic
• Motifin

Related Fabrics

• Life Sciences Fabrica
• AEGIS
• DFT
• Invariant Engineering

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